Gut microbiota as prognosis markers for patients with HBV-related acute-on-chronic liver failure

The gut microbiota in the hepatitis B virus related acute-on-chronic liver failure (HBV-ACLF) is poorly defined. We aim to uncover characteristics of HBV-ACLF and other HBV associated pathologies. analyzed microbiome patients with or pathologies healthy individuals by 16S rRNA sequencing metagenomic fecal samples. 212 HBV-ACLF, 252 chronic (CHB), 162 HBV-associated cirrhosis (HBV-LC) 877 were recruited for study. CHB HBV-LC are grouped as HBV-Other. discovered striking differences diversity between HBV-Other groups using sequencing. ratio cocci bacilli was significantly elevated group compared group. Further analysis within identified 52 genera showing distinct richness where Enterococcus enriched progression whilst Faecalibacterium regression Metagenomic validated these findings further uncovered an enrichment Lactobacillus casei paracasei group, while Alistipes senegalensis, prausnitzii Parabacteroides merdae dominated Importantly, our revealed that there a rapid increase faecium during HBV-ACLF. displayed composition at different phases High abundance Therefore, features hold promising potential prognostic markers